- Publication : 13 mai 2020
15 janvier 2021, 11h30 (diffusion en visioconférence).
Phenotypic novelties by compensatory evolution.
Synthetic and Systems Biology Unit Biological Research Center, Szeged, Hungary
Since the early 1920s, Ronald Fisher pioneered the view that adaptation is by and large a hill-climbing process: it proceeds through progressive accumulation of beneficial mutations. However, as slightly deleterious mutations are far more abundant, they have a significant contribution to genetic variation in natural populations. In the long run, the wealth of such detrimental mutations is expected to promote the fixation of compensatory mutations elsewhere in the genome. In this work, we ask whether deleterious mutations promote adaptive genetic changes and what the side consequences of such a process might be. Using laboratory evolution, we demonstrate that deleterious mutations act as stepping stones in adaptive evolution by providing access to phenotypic novelties
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