Séminaire au CEFE : Genomic epidemiology of viral infectious diseases

mercredi 17 octobre 2018 – 14h
Grande salle de réunion du CEFE | 1e étage, aile C


Julien Thézé
Department of Zoology, University of Oxford


The use of next-generation sequencing technologies has revolutionized the study of viral infectious diseases. The possibility to generate, rapidly and accurately, full viral genomes combined with phylodynamic inference enables to analyse in more detail the dynamics of viral epidemics. In this talk, I will introduce sequencing and phylodynamic inference methods and applied questions we address with them. I will then present the case study of the recent epidemic of Zika virus (ZIKV) in the Americas. I will show our main findings on the timescale of the establishment and spread of the outbreak. I will also demonstrate that varying local environmental conditions for mosquito vectors along with human movements and herd immunity have driven spatial and temporal heterogeneities of ZIKV transmission in the Americas. This work highlights the importance of integrating epidemiological and ecological data to genetic-based findings, and vice-versa.


Contact au CEFE: Sylvain GANDON