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A population genetic interpretation of GWAS findings for human quantitative traits

Guy SELLA

Department of Biological Sciences, Columbia University, USA

Le vendredi 14 septembre - 11h30 Campus Triolet Univ Montpellier: amphi 23.01 - Bât. 23

 (Seminar in English)
 
 

One of the central goals of evolutionary genetics is to understand the processes that give rise to phenotypic variation in humans and other taxa. Genome-wide association studies (GWASs) in humans provide an unprecedented opportunity in that regard, revealing the genetic basis of variation in numerous traits. However, exploiting this opportunity requires models that relate genetic and population genetic processes with the discoveries emerging from GWASs. We present such a model and show that it can help explain the results of GWASs for height and body mass index. More generally, our results offer a simple interpre-tation of the findings emerging from GWASs and suggest how they relate to the evolution-ary and genetic forces that give rise to phenotypic variation.

Related publications:
Simons YB, Bullaughey K, Hudson RR, Sella G (2018) A population genetic interpretation of GWAS findings for human quantitative traits. PLoS Biol 16(3): e2002985
Sella G, Barton NH (2017). Selection on quantitative traits. Annual Review of Genomics and Human Genetics 18:1

 
 
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