Welcome to the CEFE

The CEFE is currently the largest French research center in Ecology and Evolutionary Ecology. Our Mission: perform independent, fundamental scientific research on the dynamics of biodiversity, planetary environmental change, and sustainable development. The links between society and ecology is a theme of increasing importance in oour research.

If you are interested in who does what on a specific theme or topic at CEFE, please go to the WHO DOES WHAT tab and use the proposed tags. You will have direct access to the pages of the persons listed for a given tag.

If you are interested in what the different research Departments at cefe do and the focus of their respective teams, please go to the RESEARCH tab and navigate the Departments and their teams.

Seminars of ecology and evolution of Montpellier

  • Mathilde Dufay

    19 juin 2020, 11h30 (diffusion en visioconférence). Evolution and dynamics of a natural gene drive sys-tem in house mice, the t haplotype.

  • Samuel Alizon

    26 juin 2020, 11h30 (diffusion en visioconférence). COVID-19 crisis epidemiological modelling.

  • Simon T. Segar

    12 juin 2020, 11h30 (diffusion en visioconférence). Evolution and dynamics of a natural gene drive sys-tem in house mice, the t haplotype.

Anna Lindholm

15 Mai 2020, 11h30 (diffusion en visioconférence).

Evolution and dynamics of a natural gene drive sys-tem in house mice, the t haplotype.

Anna Lindholm

University of Zurich, Switzerland
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Cooperation between genes is needed for organisms to function, and alleles that build better organisms will out-compete their rivals and spread. However, some genetic loci increase in frequency despite reducing organismal fitness, by manipulating upwards their transmission to offspring, called drive. The transmission benefits arising from drive come at the cost of alternative alleles, and often at the cost of the whole genome, potentially leading to intra-genomic conflict. Drive systems could be used to quickly spread loci that humans find valuable throughout wild populations, even if they reduce the fitness of their carriers, for example by biasing offspring sex ratios towards males in mosquitoes. Important to the debate on whether drive systems should be introduced into wild populations is a better understanding of how drive systems spread, and how genome-wide conflicts over transmission are resolved, so that we can better predict short and long-term outcomes. The study of natural drive systems is critical in this context. In this talk, I discuss recent behavioural, ecological and genomic findings on the t haplotype, a natural autosomal meiotic driver found in house mice Mus musculus. These results may have applied relevance, as the t haplotype has been proposed as the basis of a sex ratio distorter that could be used to humanely control pest house mouse populations.

Recent publications:

1. Wedell, Price & Lindholm (2019) Gene drive: progress and prospects. Proc Roy Soc B 286 doi: 10.1098/rspb.2019.2709

2. Lindholm, Sutter, Künzel, Tautz & Rehrauer (2019) Effects of a male meiotic driver on male and female transcriptomes in the house mouse. Proc Roy Soc B286 doi: 10.1098/rspb.2019.1927

3. Runge & Lindholm (2018). Carrying a selfish genetic element predicts increased migration propensity in free-living wild house mice. Proc Roy Soc B285 doi: 10.1098/rspb.2018.1333